Research area
Aging & Longevity
Aging mechanisms, senescence, healthspan and rejuvenation interventions. Includes aging-focused works previously placed under Biology & Ecology.
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Evidence date ·Why did prolonged cell resetting damage mouse livers, and what did an antioxidant change?
Peer-Reviewed PaperIn mice, sustained cell reprogramming injured the liver. An antioxidant delayed death while measured reprogramming markers remained; regeneration was not shown.
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Evidence date ·Should researchers remove, quiet or reset senescent cells?
Review or Meta-AnalysisThe review compares ways to remove, quiet or reprogram aging cells and summarizes human studies measuring tissue changes, function and biomarkers. None establishes human age reversal.
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Evidence date ·What two molecular-age readings can reveal about one tissue
Peer-Reviewed PaperResearchers compared gene-activity clocks across four mammals and found distinct pathway shifts. Human blood readings were associated with later mortality.
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Evidence date ·How aging T cells may shape the health of organs
Review or Meta-AnalysisA 2026 review links aging T cells to inflammation and reduced clearance of senescent cells. Whether targeting T cells slows organ aging in people is unknown.
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Evidence date ·How aging cells lose the ability to maintain their mitochondria
Review or Meta-AnalysisA review examines how mitochondrial DNA changes, network shape and removal of damaged mitochondria interact as cells age. Human treatment results remain mixed.
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Evidence date ·What have marine compounds shown for the aging liver?
Review or Meta-AnalysisA 2026 review reports less liver fat and injury in animal models and improved metabolic measures in early human studies. Neither shows reversal of liver aging.
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Evidence date ·How metabolism and aging blood vessels affect each other
Review or Meta-AnalysisA 2026 review traces how glucose and fat metabolism affect aging vessel walls and other organs, and compares exercise and drug findings. Vascular improvement is not proof of reversal.
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Evidence date ·Could natural killer cells help older adults stay healthy?
Review or Meta-AnalysisA 2026 review connects aging-related changes in natural killer cells with immune surveillance. Tests and preventive treatments still need validation.
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Evidence date ·How a lifelong virus may affect health during effective HIV treatment
Review or Meta-AnalysisA 2026 review explores how cytomegalovirus may sustain inflammation during treated HIV. Early letermovir results do not show that the drug prevents illness.
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Evidence date ·Why is it so hard to choose which aging cells to remove?
Review or Meta-AnalysisA 2026 review compares immune targeting, protein degraders, and microbiome signals. Newer strategies are mainly preclinical, while human results remain limited.