Research area
Aging & Longevity
Aging mechanisms, senescence, healthspan and rejuvenation interventions. Includes aging-focused works previously placed under Biology & Ecology.
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Evidence date ·Could cell-by-cell maps guide more selective aging treatments?
Review or Meta-AnalysisA December 2025 review compares animal cell maps with human intervention studies. Cell-targeted therapies remain proposals, not proven ways to extend healthspan.
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Evidence date ·How persistent signals from aging cells may affect the kidney
Review or Meta-AnalysisA 2025 review traces how senescent cells may shape kidney inflammation and compares clearing them with quieting their signals. Human kidney benefits remain unproven.
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Evidence date ·When should aging heart cells be cleared, and when should their signals stay?
Review or Meta-AnalysisA review weighs clearing aging cells against cell therapy, showing why timing matters. Early cell-therapy studies have yet to establish lasting benefit or broad safety.
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Evidence date ·Why diabetes and aging biology intersect—and what the treatment evidence shows
Review or Meta-AnalysisA 2025 review examines how cellular pathways may link diabetes and aging. Cardiovascular benefits for some drugs do not prove slower aging.
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Evidence date ·Could clearing aging-related cells change how the heart heals?
Review or Meta-AnalysisA review links senescent cells to plaque formation. After a heart attack, clearing them may improve recovery, but some of their signals may help repair.
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Evidence date ·Why do older adults face greater infection risks during hospital care?
Review or Meta-AnalysisA 2025 review links immune aging, gut changes and hospital exposures to infection risk in older adults. Practical prevention is clearer than newer therapies.
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Evidence date ·When might clearing aging cells help, and when might quieting them fit better?
Review or Meta-AnalysisA 2025 review compares drugs that remove senescent cells with those that quiet their inflammatory signals, and weighs early disease studies against measurement and safety limits.
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Evidence date ·How does kidney disease change immune defenses, and why can treatment complicate recovery?
Review or Meta-AnalysisA 2025 review links retained toxins and oxidative stress to immune aging in kidney disease, and explains the different pressures from dialysis and transplant drugs.
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Evidence date ·Why can aging immunity weaken while inflammation persists?
Review or Meta-AnalysisA 2025 review links weaker immune defenses with persistent inflammation. One trial raised antiviral gene expression without clearly reducing respiratory illness.
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Evidence date ·Why did a treatment help frail male mice live longer, but not females?
Peer-Reviewed PaperOxytocin plus an ALK5 inhibitor extended survival and improved function in old male mice. Females showed early protein changes but no healthspan gain.