Research area
Aging & Longevity
Aging mechanisms, senescence, healthspan and rejuvenation interventions. Includes aging-focused works previously placed under Biology & Ecology.
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Evidence date ·Why is it so hard to choose which aging cells to remove?
Review or Meta-AnalysisA 2026 review compares immune targeting, protein degraders, and microbiome signals. Newer strategies are mainly preclinical, while human results remain limited.
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Evidence date ·Senescence-focused DNA scores stayed level or rose after treatment
Peer-Reviewed PaperResearchers trained three DNA methylation scores to predict senescence, age or mortality. None fell significantly after senolytic treatment in the datasets tested.
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Evidence date ·How aging stem cells and their marrow surroundings reshape blood production
Review or Meta-AnalysisAging blood stem cells, marrow changes, and expanding clones may affect immunity and other organs. Restoring human blood production remains unproven.
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Evidence date ·Can inflammation warn of future walking problems, and what can that warning do?
Review or Meta-AnalysisA 2026 review traces possible effects of inflammation on muscle, joints and balance, and separates risk markers from evidence for exercise and rehabilitation.
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Evidence date ·How stress inside stem cells and nearby senescent cells can shape repair
Peer-Reviewed PaperA review traces how stress inside stem cells and signals from senescent neighbors can shape repair or decline. Proposed controls are not proven human treatments.
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Evidence date ·How an aging ovary’s support system may shape egg quality
Review or Meta-AnalysisThe review explains how support cells fuel egg development and how mitochondrial stress and inflammation may interfere. Proposed treatments remain unproven in people.
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Evidence date ·Should lingering stressed cells be cleared, quieted or restored?
Review or Meta-AnalysisA 2026 review compares ways to remove senescent cells, quiet their signals, recruit immune defenses or restore function. Human benefit and safety remain uncertain.
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Evidence date ·How aging-cell signals and faltering cleanup affect the heart and arteries
Review or Meta-AnalysisA 2026 review examines senescent cells in plaques and aging hearts, animal treatment findings, and why benefits for patients remain unproven.
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Evidence date ·A younger cell is not yet a repaired tissue
Review or Meta-AnalysisSmall molecules can change cell identity and age-related features in lab and animal studies. Human findings involve related compounds, not cell reprogramming.
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Evidence date ·What changed in fat and immune cells after obese-donor plasma?
Peer-Reviewed PaperMice given obese-donor plasma had higher aging-related markers in fat and immune cells than controls; weight and two plasma cytokines did not differ significantly.