Research area
Aging & Longevity
Aging mechanisms, senescence, healthspan and rejuvenation interventions. Includes aging-focused works previously placed under Biology & Ecology.
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Evidence date ·When cells stop dividing, should we remove them or change their signals?
Review or Meta-AnalysisA 2022 review explains cell removal, signal suppression and sequential cancer treatment, with tissue risks and human benefits still unresolved.
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Evidence date ·Quieting harmful cell secretions or removing their source
Review or Meta-AnalysisA March 2023 review compares changing cell secretions with removing cells, and explains why lower senescence markers alone do not prove patient benefit.
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Evidence date ·What changes when a drug targets cells that have stopped dividing?
Review or Meta-AnalysisAn April 2022 review explains how scientists identify senescent cells, distinguish killing from quieter secretions, and assess prospects for human benefit.
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Evidence date ·How nutritional compounds might change or remove senescent cells
Review or Meta-AnalysisA June 2022 narrative review explores changes in senescent cells, their secretions and survival—and what those experiments can tell us about human diets.
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Evidence date ·Removing persistent cells or quieting their signals in cancer and HIV
Review or Meta-AnalysisA 2022 review explores cell clearance versus signal suppression, with mouse cancer results and HIV trial markers that stop short of proven patient benefit.
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Evidence date ·How gut microbes and senescent cells could reshape the intestinal environment
Review or Meta-AnalysisExplore how microbial products could affect cellular senescence and the gut barrier, and what mouse findings in a January 2022 review actually establish.
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Evidence date ·Why would treatments remove cells that stop dividing—or make others stop?
Review or Meta-AnalysisA 2021 review explains how senescent cells shape tissue repair, why treatments remove or induce them, and what limits conclusions about patient benefit.
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Evidence date ·Could targeting senescent cells interrupt chronic inflammation?
Review or Meta-AnalysisA 2021 review explains how senolytics and senomorphics target senescent cells differently, and why entering trials does not establish patient benefit.