Research area
Health & Longevity
Human health, disease, treatment and aging. The largest corpus area supports distinct cancer, neurological and therapeutic navigation.
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Evidence date ·A brainstem arousal hub is linked to slow sleep rhythms in Alzheimer’s disease
Peer-Reviewed PaperTracked over timeBrain scans and overnight recordings in 58 adults linked a brainstem sleep hub to slow-wave strength, not simply time spent in deep sleep.
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Evidence date ·How an overactive arousal circuit shaped sleep in amyloid-model mice
Peer-Reviewed PaperTracked over timeIn mice modeling Alzheimer’s disease, an arousal circuit was overactive. Drugs improved selected sleep measures, but benefits for people remain unproven.
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Evidence date ·Why the locus coeruleus matters during sleep and Alzheimer’s research
Review or Meta-AnalysisTracked over timeA 2022 review weighs animal experiments and human observations on how a brainstem wakefulness system might link disrupted sleep and Alzheimer’s disease.
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Evidence date ·How researchers plan to compare brain signals during sound-assisted sleep
Clinical TrialA January 2022 trial registration proposes comparing scalp and implanted brain signals during sleep to test slow-wave detection in people with Parkinson’s.
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Evidence date ·What a dialysis-fluid creatine pilot could really show
Clinical TrialA planned 16-person pilot would test creatine in dialysis fluid for feasibility and safety, measuring blood-cell creatine, strength, fatigue and cognition.
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Evidence date ·Could changing time in bed affect sleep and memory in older adults?
Clinical TrialA proposed four-week study asks whether limiting time in bed can deepen sleep and affect memory-related brain function in older adults at Alzheimer’s risk.
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Evidence date ·Why researchers proposed removing stressed support cells in amyotrophic lateral sclerosis
Review or Meta-AnalysisA 2021 review considers removing senescent support cells in ALS, weighing evidence from other diseases against risks to motor neurons and blood cells.
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Evidence date ·How researchers find and redesign drugs for senescent cells
Review or Meta-AnalysisA 2021 review compares screening, enzyme-activated drugs, and protein degraders for clearing senescent cells—and why clinical benefit needs separate proof.
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Evidence date ·How researchers might target cells that have stopped dividing
Review or Meta-AnalysisA 2021 review compares suppressing signals from cells that stopped dividing with removing them, then weighs early human functional and biomarker findings.
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Evidence date ·What an omega-3 experiment revealed about aging-linked signals after kidney transplant
Peer-Reviewed PaperAn exploratory 44-week randomized transplant trial found omega-3 altered five senescence-linked blood proteins; kidney-function benefit remained unproven.