Research area
Brain Health & Neurology
Brain function, neurological disease, dementia and neurological treatment and care.
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Evidence date ·What changes in the aging brain’s waste-removal system?
Review or Meta-AnalysisA 2024 review connects aging, sleep rhythms, blood vessels, and brain fluid drainage. Whether improving clearance can protect memory in people remains unknown.
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Evidence date ·Could immune aging change how multiple sclerosis progresses and is treated?
Review or Meta-AnalysisA review links age-related immune change to distinct multiple sclerosis patterns and harder treatment choices, while older-patient evidence remains limited.
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Evidence date ·The same drug brought different maze results in male and female mice
Peer-Reviewed PaperTracked over timeIn atherosclerotic mice, treatment improved memory in males but delayed learning in females; the study does not show why or whether people would respond similarly.
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Evidence date ·What happened when treatment began before memory problems in mice?
Peer-Reviewed PaperTracked over timeMonthly dasatinib plus quercetin improved spatial memory in female Alzheimer’s-model mice. Males showed no corresponding memory benefit.
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Evidence date ·How exercise may support the blood vessels of an aging brain
Review or Meta-AnalysisA 2024 review explores how exercise may support brain blood flow and the blood–brain barrier, but does not establish lasting benefits for thinking and memory.
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Evidence date ·How aging-related cell changes may shape movement loss in ALS
Review or Meta-AnalysisA May 2024 review links ALS, a motor neuron disease, with biological aging and inflammation, and explains why senolytics remain unproven as an ALS therapy.
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Evidence date ·Why stressed brain-support cells are being studied in Alzheimer’s
Review or Meta-AnalysisA 2024 review compares removing senescent brain cells with quieting their harmful signals, and explains why neither yet proves patient benefit.
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Evidence date ·Can clearing senescent cells change how an aging mouse brain handles seizures?
Peer-Reviewed PaperTracked over timeAged mice got months of dasatinib and quercetin before induced status epilepticus, with better survival but no later memory advantage; recurrent seizures were not evaluated.
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Evidence date ·Could targeting abnormal brain cells reduce seizures in mice?
Peer-Reviewed PaperTracked over timeHuman surgical tissue pointed to senescent cells as a target; a mouse study then tested dasatinib and quercetin, with seizures falling after treatment.
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Evidence date ·What Alzheimer’s medicines can do for decline, symptoms, and daily life
Review or Meta-AnalysisA 2024 review compares drugs that slow measured decline with treatments for sleep and agitation, while showing why scans alone are not enough.