Research area
Brain Health & Neurology
Brain function, neurological disease, dementia and neurological treatment and care.
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Evidence date ·How researchers bring age-related disease biology into human neurons
Review or Meta-AnalysisA 2024 review compares neuron-making routes and senescence experiments for late-onset disease, while separating lab-induced features from natural brain aging.
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Evidence date ·How a planned 12-week melatonin comparison will measure sleep, memory, movement and blood markers
Clinical TrialTracked over timeA 12-week randomized study compares melatonin with sleep-hygiene education while tracking blood markers, cognition, sleep and movement; results are not posted.
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Evidence date ·How a nighttime hormone might affect Alzheimer’s brain changes
Review or Meta-AnalysisTracked over timeAn August 2024 review links melatonin to sleep, amyloid and tau mechanisms, but human cognitive gains still do not prove Alzheimer’s protection.
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Evidence date ·Why timing changes the story of melatonin in Alzheimer’s disease
Review or Meta-AnalysisTracked over timeA 2024 review weighs melatonin’s mixed sleep and cognitive findings, safety questions and the case for testing treatment earlier in Alzheimer’s disease.
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Evidence date ·How brain fluid movement may relate to amyloid buildup
Peer-Reviewed PaperA 50-person study linked two brain-fluid measurements to amyloid levels. The findings do not establish cause or predict future dementia.
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Evidence date ·How nighttime lighting may connect sleep and Alzheimer’s biology
Review or Meta-AnalysisA 2023 review traces how nighttime light can disrupt the body clock and sleep, then compares animal studies, human observations, and timed dementia-care lighting.
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Evidence date ·When brain immune cells age, could iron and cell removal matter?
Review or Meta-AnalysisTracked over timeA 2024 review connects stressed microglia with iron handling and senolytic drugs, while mouse memory gains involve more than one cell type.
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Evidence date ·How aging changes brain immune cells in female and male mice
Peer-Reviewed PaperTracked over timeResearchers compare young and old male and female mice to trace microglial gene and cell-marker changes, while the Alzheimer’s link remains a hypothesis.
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Evidence date ·How a mitochondrial membrane change altered creatine entry in cultured brain-vessel cells
Peer-Reviewed PaperResearchers lowered cardiolipin in cultured human brain-vessel cells and found less creatine uptake while total ATP stayed stable; brain delivery remains untested.
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Evidence date ·How cellular defenses relate to memory in mice carrying abnormal human tau
Peer-Reviewed PaperIn mice carrying abnormal human tau, loss of a cell-defense regulator was linked to maze deficits without a further rise in markers of cell senescence.