Research area
Brain Health & Neurology
Brain function, neurological disease, dementia and neurological treatment and care.
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Evidence date ·What can Alzheimer’s laboratory models tell us before treatments reach people?
Review or Meta-AnalysisA 2025 review compares cell cultures, animal models, and behavior tests in Alzheimer’s research. It shows why none can prove that a treatment helps people.
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Evidence date ·Could aging-related changes in brain cells matter for ALS treatment?
Review or Meta-AnalysisA 2025 review draws on patient samples and ALS models and discusses a rapamycin trial. Whether clearing senescent cells would help patients remains unknown.
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Evidence date ·Could clearer sight support cognitive health?
Review or Meta-AnalysisA review describes mixed cognitive findings after cataract surgery. Some studies report lower dementia risk or better test scores, but prevention remains unproven.
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Evidence date ·What changes with age after a spinal cord injury?
Review or Meta-AnalysisA 2025 review examines how inflammation can persist after spinal cord injury and discusses treatments studied in animals. Whether they help older patients remains unknown.
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Evidence date ·How researchers could detect blood vessel damage alongside other causes of dementia
Peer-Reviewed PaperA 2025 workshop described blood proteins and brain scans as possible clues to vascular contributions to dementia. None is yet a proven test for individual diagnosis.
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Evidence date ·What happened to sleep when Alzheimer’s-model mice could run?
Peer-Reviewed PaperMale mice with an Alzheimer’s-like condition slept more during their usual rest phase after two months with running wheels. Human benefit remains untested.
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Evidence date ·What do early patient observations mean for a neck operation for Alzheimer’s?
Review or Meta-AnalysisTracked over timeA 26-person study reported mixed results one month after a neck lymphatic bypass. Controlled trials are needed to learn whether patients benefit.
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Evidence date ·A proposed neck operation puts Alzheimer’s drainage theory to a human test
Clinical TrialTracked over timeThe registry describes a proposed 20-person study with a cognitive test at six months. Its one-group design cannot directly compare surgery with other care.
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Evidence date ·How cPLA2 may link brain inflammation and cellular senescence
Review or Meta-AnalysisA 2024 review links cPLA2 to brain inflammation and describes a virtual screen of over 20 billion compounds. Whether any candidate helps patients remains unknown.
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Evidence date ·What changes in the aging brain’s waste-removal system?
Review or Meta-AnalysisA 2024 review connects aging, sleep rhythms, blood vessels, and brain fluid drainage. Whether improving clearance can protect memory in people remains unknown.