Research area
Brain Health & Neurology
Brain function, neurological disease, dementia and neurological treatment and care.
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Evidence date ·How did reported sleep relate to brain and cognitive change across AQP4 gene groups?
Peer-Reviewed PaperIn adults with amyloid buildup, links between reported sleep and brain atrophy or cognitive decline varied by gene group. No sleep intervention was tested.
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Evidence date ·What a small study found about brain creatine and concentration in perimenopause
Peer-Reviewed PaperA study of 12 perimenopausal women linked creatine in three brain regions to concentration difficulty. Its single snapshot cannot show cause or treatment benefit.
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Evidence date ·How might aging immune defenses leave the brain more vulnerable?
Review or Meta-AnalysisThe review traces how weaker immune responses, senescent brain cells and barrier changes may sustain inflammation. Human findings remain mostly associative.
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Evidence date ·Could SIRT1 activation help preserve memory as the brain ages?
Review or Meta-AnalysisA 2026 review surveys mouse studies linking SIRT1 activity to cognition and discusses resveratrol, metformin and exercise. Human memory benefits remain unproven.
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Evidence date ·Could targeting stressed brain cells help people with neurodegenerative disease?
Review or Meta-AnalysisA review describes signs of senescence in different brain cells across Alzheimer’s, Parkinson’s and multiple sclerosis. A five-person pilot found no significant cognitive change.
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Evidence date ·What changed in mouse memory and brain immune cells after resveratrol?
Peer-Reviewed PaperIn an accelerated-aging mouse model, resveratrol improved maze performance and lowered brain inflammatory markers. Cultured cells showed reduced STING pathway signaling.
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Evidence date ·What did scans and blood tests find in personnel with years of blast exposure?
Peer-Reviewed PaperResearchers compared brain scans and blood markers in active-duty personnel with long blast-exposure histories. A small, one-time study cannot establish cause or future risk.
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Evidence date ·How a deep brain sleep circuit might connect Alzheimer’s with overnight memory
Review or Meta-AnalysisThalamic changes may link disrupted sleep rhythms to memory loss in Alzheimer’s. Mouse results offer clues; direct thalamic treatment in people is unproven.
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Evidence date ·Why can similar signs of brain inflammation mean different things in disease and aging?
Review or Meta-AnalysisThe review compares microglia and astrocytes in Alzheimer’s disease, ALS and aging. Mouse interventions and cell profiles offer clues, not proof of human treatment.
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Evidence date ·Could an Alzheimer’s-linked protein signal protect sleep and the brain’s blood-vessel barrier?
Peer-Reviewed PaperNewborn Alzheimer’s-model mice received a viral construct encoding an engineered APP fragment. Later, they slept more in the dark phase and less tracer entered the brain.