Research area
Health & Longevity
Human health, disease, treatment and aging. The largest corpus area supports distinct cancer, neurological and therapeutic navigation.
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Evidence date ·Why is it so hard to choose which aging cells to remove?
Review or Meta-AnalysisA 2026 review compares immune targeting, protein degraders, and microbiome signals. Newer strategies are mainly preclinical, while human results remain limited.
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Evidence date ·What does an improved MRI score reveal about cognitive decline?
Peer-Reviewed PaperA revised MRI score showed slightly stronger correlations with cognitive assessments in a 50-sample test set. Its sleep-quality correlation was weak and nonsignificant.
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Evidence date ·How a deep brain sleep circuit might connect Alzheimer’s with overnight memory
Review or Meta-AnalysisThalamic changes may link disrupted sleep rhythms to memory loss in Alzheimer’s. Mouse results offer clues; direct thalamic treatment in people is unproven.
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Evidence date ·Senescence-focused DNA scores stayed level or rose after treatment
Peer-Reviewed PaperResearchers trained three DNA methylation scores to predict senescence, age or mortality. None fell significantly after senolytic treatment in the datasets tested.
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Evidence date ·Can a kidney’s early environment shape its resilience later in life?
Review or Meta-AnalysisThe review traces kidney vulnerability from pregnancy through childhood and aging. Early prevention remains a proposal, not a demonstrated outcome.
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Evidence date ·Why can similar signs of brain inflammation mean different things in disease and aging?
Review or Meta-AnalysisThe review compares microglia and astrocytes in Alzheimer’s disease, ALS and aging. Mouse interventions and cell profiles offer clues, not proof of human treatment.
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Evidence date ·When liver scar-forming cells help repair and sustain inflammation
Review or Meta-AnalysisA February 2026 review traces how senescent liver stellate cells can limit scarring or sustain inflammation. It does not establish a treatment for patients.
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Evidence date ·Could sleep apnea change the brain before thinking problems appear?
Peer-Reviewed PaperPET scans showed lower frontoparietal and higher cerebellar glucose uptake in adults with sleep apnea than in older controls. The study cannot show progression.
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Evidence date ·Could an Alzheimer’s-linked protein signal protect sleep and the brain’s blood-vessel barrier?
Peer-Reviewed PaperNewborn Alzheimer’s-model mice received a viral construct encoding an engineered APP fragment. Later, they slept more in the dark phase and less tracer entered the brain.
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Evidence date ·How aging stem cells and their marrow surroundings reshape blood production
Review or Meta-AnalysisAging blood stem cells, marrow changes, and expanding clones may affect immunity and other organs. Restoring human blood production remains unproven.