Research area
Health & Longevity
Human health, disease, treatment and aging. The largest corpus area supports distinct cancer, neurological and therapeutic navigation.
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Evidence date ·Should cancer treatment remove impaired T cells or restore them?
Review or Meta-AnalysisTracked over timeA review explains why aged T cells may lose the ability to multiply yet retain tumor-killing activity, and how restoration differs from removal.
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Evidence date ·When aging changes the immune neighborhood around a tumor
Review or Meta-AnalysisTracked over timeA 2021 review reports mixed findings on age and cancer immunotherapy. Removing senescent cells to improve treatment was still an unproven proposal.
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Evidence date ·How blood and urine tests could probe a cellular role in long COVID
Clinical TrialA 2021 registry planned blood and urine tests for senescence, inflammation and auto-antibodies to assess whether a future drug trial could be justified.
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Evidence date ·NiteCAPP asks whether web-based insomnia care can fit family caregiving
Clinical TrialNiteCAPP’s planned study would assess online insomnia therapy for rural dementia caregivers, with assessments after treatment and at six and twelve months.
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Evidence date ·How targeting ageing-related cells might protect blood vessels
Review or Meta-AnalysisA 2021 review weighs animal evidence for targeting senescent cells in the heart and blood vessels, while human cardiovascular benefit remains unproven.
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Evidence date ·How could senescent-cell medicines improve everyday health?
Review or Meta-AnalysisAn NIA workshop report examines a small lung-disease study and why markers, coexisting illnesses, and other medicines shape senolytic trials.
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Evidence date ·How changing culture temperature made an engineered kidney cell model useful for testing drugs aimed at senescent cells
Peer-Reviewed PaperTracked over timeResearchers shifted engineered human kidney cells from 33°C to 37°C and found that some drugs reduced viability more in cells with senescence-like features.
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Evidence date ·How nondividing cells can still affect kidney health
Review or Meta-AnalysisTracked over timeMouse experiments removing p16-positive cells, plus a 2021 review of senolytics and donor-kidney perfusion, show why human benefit remains uncertain.
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Evidence date ·What a three-way study of sleep, exercise, and dementia risk can show
Clinical TrialA registered study compares sleep support, exercise, and both over 12 weeks. Its protocol describes planned measurements, not demonstrated dementia prevention.
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Evidence date ·How cells that stop dividing might connect aging to severe COVID-19
Review or Meta-AnalysisA 2021 review connects immune aging, senescent-cell signals and ACE2’s two roles, then weighs how far evidence from other viruses can support treatment ideas.