Research area
Health & Longevity
Human health, disease, treatment and aging. The largest corpus area supports distinct cancer, neurological and therapeutic navigation.
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Evidence date ·Cell removal produces conflicting results in animal models of lung artery disease
Review or Meta-AnalysisA 2024 review compares animal studies in which removing senescent cells helped or harmed lung arteries. Benefits in people remain unproven.
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Evidence date ·Could changing how immune and lung cells use energy control chronic inflammation?
Review or Meta-AnalysisAn EAACI position paper connects cellular energy use with persistent lung inflammation, separating patient observations from experimental treatment evidence.
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Evidence date ·Can aging treatments extend healthy life without harming repair?
Review or Meta-AnalysisClearing senescent cells benefited aged mice but impaired repair in young mouse lungs. These findings leave human benefits and safe targeting unresolved.
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Evidence date ·Aging immunity needs repair at several levels
Review or Meta-AnalysisA July 2023 review explains why aging can leave immunity inflamed yet fragile, and contrasts cell repair, senescent-cell removal and targeted delivery.
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Evidence date ·What dasatinib plus quercetin did beyond eating less in monkeys
Peer-Reviewed PaperIn 16 macaques, dasatinib plus quercetin altered selected biomarkers and may have added to calorie restriction’s effect on HbA1c, a blood-sugar measure.
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Evidence date ·How aging changes the timing and coordination of the COVID-19 immune response
Review or Meta-AnalysisA December 2021 review links delayed antiviral signals, narrower immune recognition and comorbidities to COVID-19 vulnerability; treatment benefits remain unproven.
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Evidence date ·How cell maintenance can shape the health of whole organs
Review or Meta-AnalysisA 2022 synthesis links protein maintenance, autophagy and senescent-cell signals to organ function, while clinical outcomes remain disease-specific.
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Evidence date ·How senescent cells may help repair tissue before immune clearance
Review or Meta-AnalysisA 2021 review explains how living, non-dividing cells can guide repair, why immune clearance matters, and what early human studies can show.
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Evidence date ·How aging changes the immune response to COVID-19
Review or Meta-AnalysisA January 2021 review links immune aging to delayed antiviral signals and inflammation, but does not establish how much each contributes to severe COVID-19.
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Evidence date ·Why clearing some stressed cells might preserve function with age
Review or Meta-AnalysisA January 2021 review reports changes in tissue markers and walking ability in early senolytic studies, without proving clinical benefit.