Research area
Aging & Longevity
Aging mechanisms, senescence, healthspan and rejuvenation interventions. Includes aging-focused works previously placed under Biology & Ecology.
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Evidence date ·Why cancer drugs are being studied in cells that have stopped dividing
Review or Meta-AnalysisA 2025 review connects cancer drugs with senescent-cell survival pathways. Lab and animal examples, plus trial listings, do not establish patient benefit.
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Evidence date ·How inflammation linked to aging reaches the arteries and heart
Review or Meta-AnalysisThe review traces how aging-related immune changes affect arteries and the heart, and weighs human anti-inflammatory trials against experimental senescent-cell therapies.
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Evidence date ·What blood, heart and vessel measurements reveal about cardiovascular aging
Review or Meta-AnalysisA 2025 review compares blood markers, heart imaging and vessel tests for cardiovascular aging. Their ability to improve prevention remains uncertain.
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Evidence date ·How could immune aging make bones more fragile?
Review or Meta-AnalysisA 2025 review links aging immune cells with bone loss. Drugs improved bone measures in mice, but immune-based treatments and risk tests need human validation.
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Evidence date ·What have cell treatments changed in animals and people?
Review or Meta-AnalysisA 2025 review reports longer survival in some animal studies and changes in walking distance and immune markers in early human trials. Lasting benefits remain unproven.
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Evidence date ·What the evidence says about fat’s early role in aging
Review or Meta-AnalysisA 2025 review examines changes in fat storage and immune signaling. Mouse findings suggest an early role, but human studies cannot show fat drives aging elsewhere.
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Evidence date ·When can a protective cell-cycle stop become a treatment problem?
Review or Meta-AnalysisA 2025 review traces how DNA damage stops cell division and how senescent cells affect nearby tissue. A 14-person lung-fibrosis pilot offers early clues.
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Evidence date ·How aging and artery plaque may affect each other
Review or Meta-AnalysisA June 2025 review explores how artery plaque may affect the brain, kidneys and muscles as we age. Senolytics have yet to show cardiovascular benefits in people.
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Evidence date ·Why fixing damaged DNA in ageing cells is promising and hard to control
Review or Meta-AnalysisA June 2025 Perspective reviews coordinated DNA repair experiments and disease-specific trials. Their results do not establish slower ageing in people.
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Evidence date ·What can tiny living tissue models reveal about aging?
Review or Meta-AnalysisMicrofluidic chips model barrier behavior under controlled flow. Their ability to predict treatment benefits in people remains unproven.