Research area
Health & Longevity
Human health, disease, treatment and aging. The largest corpus area supports distinct cancer, neurological and therapeutic navigation.
-
Evidence date ·What a lab-grown colorectal tumor can reveal before treatment
Review or Meta-AnalysisA 2025 review describes links between drug responses in colorectal tumor cultures and patients' responses to chemotherapy. Whether such testing improves care is unknown.
-
Evidence date ·Three ways to calculate a brain MRI score—and what each changes
Peer-Reviewed PaperIn MRI data from 172 older adults, head pitch was linked to the uncorrected DTI-ALPS score but not to two adjusted versions. None directly measures brain fluid flow.
-
Evidence date ·Could clearing aging-related cells change how the heart heals?
Review or Meta-AnalysisA review links senescent cells to plaque formation. After a heart attack, clearing them may improve recovery, but some of their signals may help repair.
-
Evidence date ·Why do older adults face greater infection risks during hospital care?
Review or Meta-AnalysisA 2025 review links immune aging, gut changes and hospital exposures to infection risk in older adults. Practical prevention is clearer than newer therapies.
-
Evidence date ·How stressed nerve and immune cells may keep pain signals active
Review or Meta-AnalysisA 2025 review links lasting stress in nerve and immune cells to persistent pain signals and altered spinal processing. The proposed mechanisms are not established treatments.
-
Evidence date ·Why can damaged brain vessels keep harming thinking after risk management begins?
Review or Meta-AnalysisA 2025 review links small-vessel injury to blood–brain barrier leakage and white matter damage. Proposed targeted treatments still need clinical proof.
-
Evidence date ·When might clearing aging cells help, and when might quieting them fit better?
Review or Meta-AnalysisA 2025 review compares drugs that remove senescent cells with those that quiet their inflammatory signals, and weighs early disease studies against measurement and safety limits.
-
Evidence date ·What could engineered immune cells safely target in aging and Alzheimer’s?
Review or Meta-AnalysisA 2025 review describes senescent-cell targeting in animals and amyloid removal by engineered macrophages in mice. Human benefit remains untested.
-
Evidence date ·How might fat tissue and aging cells affect a painful joint?
Review or Meta-AnalysisThe review traces inflammatory signals from fat tissue to cartilage and considers how aging cells may amplify them. Human treatment evidence remains mixed.
-
Evidence date ·How does kidney disease change immune defenses, and why can treatment complicate recovery?
Review or Meta-AnalysisA 2025 review links retained toxins and oxidative stress to immune aging in kidney disease, and explains the different pressures from dialysis and transplant drugs.