Research area
Brain Health & Neurology
Brain function, neurological disease, dementia and neurological treatment and care.
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Evidence date ·Could removing dysfunctional support cells help protect aging neurons?
Review or Meta-AnalysisA 2025 review examines senolytics for brain aging. Memory gains in injured mice and mixed human biomarker changes do not establish cognitive benefit in people.
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Evidence date ·When Alzheimer’s disrupts the body clock, what can better sleep change?
Review or Meta-AnalysisA 2025 review links sleep and body-clock disruption with Alzheimer’s biology, but whether circadian treatments can slow the disease remains unproven.
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Evidence date ·What a brain scan can reveal about disease timing after acting out dreams
Peer-Reviewed PaperTracked over timeA study of REM sleep behavior disorder linked an MRI marker to disease timing, but did not establish a way to predict an individual’s progression.
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Evidence date ·What brain measurements reveal about hand and walking changes in isolated REM sleep behavior disorder
Peer-Reviewed PaperTracked over timeIn 44 people with isolated REM sleep behavior disorder, MRI findings accompanied subtle movement differences. The study did not test future disease risk.
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Evidence date ·What follow-up revealed after a sleep disorder that makes people act out dreams
Peer-Reviewed PaperTracked over timeA five-center MRI study linked a lower left-sided brain index with later Parkinson diagnoses, but the result is not a personal forecast.
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Evidence date ·How brain changes may connect with walking after hydrocephalus shunt surgery
Clinical TrialA ClinicalTrials.gov record describes brain scans, biomarkers and a 10% walking-speed threshold around shunt surgery, with no results posted.
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Evidence date ·A concussion trial tests heart-rate feedback against education
Clinical TrialA registered trial compares coached breathing with live heart-rate feedback against concussion education and measures symptom change without posted results.
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Evidence date ·Why researchers propose combining drugs to support aging brain cells
Review or Meta-AnalysisA 2025 review proposes pairing drugs that start cellular recycling with others that support lysosomal breakdown, but evidence remains mixed.
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Evidence date ·A trial tests whether adalimumab can delay movement or memory problems in REM sleep behavior disorder
Clinical TrialA phase 2 trial compares adalimumab with placebo in REM sleep behavior disorder, pairing brain scans with clinical milestones and safety checks. Results are not posted.
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Evidence date ·Brain creatine rose in an Alzheimer’s pilot, but cognitive benefits remain uncertain
Peer-Reviewed PaperIn a 20-person, eight-week pilot, brain creatine rose and some test scores improved. Without a control group, treatment benefits remain uncertain.