Research area
Biomedical Research Methods
Experimental disease models, clinical trial design and tools for biomedical investigation.
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Evidence date ·What immune cells reveal in patient-derived liver tumor models
Review or Meta-AnalysisResearchers pair liver tumor organoids with immune cells to study treatment resistance. Clinical studies must show whether results predict patient responses.
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Evidence date ·What a lab-grown colorectal tumor can reveal before treatment
Review or Meta-AnalysisA 2025 review describes links between drug responses in colorectal tumor cultures and patients' responses to chemotherapy. Whether such testing improves care is unknown.
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Evidence date ·What tumor models can miss about engineered T cells in patients
Review or Meta-AnalysisA 2025 review explains why CAR-T cells that kill cancer cells in simple tests can still struggle to reach and remain active in solid tumors.
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Evidence date ·Why colorectal cancer looks different in a dish, a sphere, and a mouse
Review or Meta-AnalysisThe review compares cell cultures, mouse models, and newer platforms for studying colorectal cancer. Whether they can predict an individual’s response remains unproven.
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Evidence date ·What human tumor grafts on a chick embryo reveal about CAR T cells
Peer-Reviewed PaperResearchers grew HER2-positive and HER2-negative tumors on a chick embryo membrane, then measured a four-day CAR T-cell response in this preclinical model.
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Evidence date ·What patient questionnaires reveal when treatment assignments are known
Review or Meta-AnalysisA review of 23 immunotherapy trials found no baseline design-related difference in questionnaire completion or scores, while follow-up effects remained unresolved.
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Evidence date ·A planned study links device readings with brain scans and morning cognition
Clinical TrialA registered study plans to compare sleep and wake device readings with brain scans, blood biomarkers and morning cognition. Each comparison asks a different question.