Research area
Health & Longevity
Human health, disease, treatment and aging. The largest corpus area supports distinct cancer, neurological and therapeutic navigation.
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Evidence date ·How clearing cells that stopped dividing might help people function better
Review or Meta-AnalysisAn October 2021 review reports early human findings on senolytic drugs and explains why clearing senescent cells is not yet proof of patient benefit.
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Evidence date ·Caregiver stress, sleep and heart regulation in the Cereset study
Clinical TrialA registered study plan pairs heart measurements with reports of sleep, stress and burden in dementia caregivers. Benefits remain to be established.
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Evidence date ·A brainstem arousal hub is linked to slow sleep rhythms in Alzheimer’s disease
Peer-Reviewed PaperTracked over timeBrain scans and overnight recordings in 58 adults linked a brainstem sleep hub to slow-wave strength, not simply time spent in deep sleep.
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Evidence date ·How an overactive arousal circuit shaped sleep in amyloid-model mice
Peer-Reviewed PaperTracked over timeIn mice modeling Alzheimer’s disease, an arousal circuit was overactive. Drugs improved selected sleep measures, but benefits for people remain unproven.
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Evidence date ·Why the locus coeruleus matters during sleep and Alzheimer’s research
Review or Meta-AnalysisTracked over timeA 2022 review weighs animal experiments and human observations on how a brainstem wakefulness system might link disrupted sleep and Alzheimer’s disease.
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Evidence date ·How researchers plan to compare brain signals during sound-assisted sleep
Clinical TrialA January 2022 trial registration proposes comparing scalp and implanted brain signals during sleep to test slow-wave detection in people with Parkinson’s.
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Evidence date ·What a dialysis-fluid creatine pilot could really show
Clinical TrialA planned 16-person pilot would test creatine in dialysis fluid for feasibility and safety, measuring blood-cell creatine, strength, fatigue and cognition.
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Evidence date ·Could changing time in bed affect sleep and memory in older adults?
Clinical TrialA proposed four-week study asks whether limiting time in bed can deepen sleep and affect memory-related brain function in older adults at Alzheimer’s risk.
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Evidence date ·Why researchers proposed removing stressed support cells in amyotrophic lateral sclerosis
Review or Meta-AnalysisA 2021 review considers removing senescent support cells in ALS, weighing evidence from other diseases against risks to motor neurons and blood cells.
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Evidence date ·How researchers find and redesign drugs for senescent cells
Review or Meta-AnalysisA 2021 review compares screening, enzyme-activated drugs, and protein degraders for clearing senescent cells—and why clinical benefit needs separate proof.