Research area
Health & Longevity
Human health, disease, treatment and aging. The largest corpus area supports distinct cancer, neurological and therapeutic navigation.
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Evidence date ·Removing persistent cells or quieting their signals in cancer and HIV
Review or Meta-AnalysisA 2022 review explores cell clearance versus signal suppression, with mouse cancer results and HIV trial markers that stop short of proven patient benefit.
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Evidence date ·How gut microbes and senescent cells could reshape the intestinal environment
Review or Meta-AnalysisExplore how microbial products could affect cellular senescence and the gut barrier, and what mouse findings in a January 2022 review actually establish.
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Evidence date ·Why would treatments remove cells that stop dividing—or make others stop?
Review or Meta-AnalysisA 2021 review explains how senescent cells shape tissue repair, why treatments remove or induce them, and what limits conclusions about patient benefit.
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Evidence date ·Why creatine can run short during dialysis and how replacement might work
Peer-Reviewed PaperA 2021 proposal explains why dialysis patients may run short of creatine, how dialysis fluid could replace it, and what a planned pilot would measure.
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Evidence date ·Different childhood symptoms led to a diagnosis of GAMT deficiency, an inherited creatine production disorder
Review or Meta-AnalysisTracked over timeTwo children with GAMT deficiency, an inherited creatine production disorder, show how diagnosis and follow-up connect seizures, urine tests, and learning.
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Evidence date ·What can creatine-deficient mice reveal about brain development?
Review or Meta-AnalysisTracked over timeA 2021 review examines a genetic defect in creatine production, mixed findings across mouse behavior tests, and possibilities for treatment research.
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Evidence date ·Why did adding an antidepressant change creatine’s effects in rats at altitude?
Peer-Reviewed PaperAn altitude rat experiment reveals how adding fluoxetine changed behavioral results, and why brain chemistry alone cannot establish a human therapy.
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Evidence date ·Could targeting senescent cells interrupt chronic inflammation?
Review or Meta-AnalysisA 2021 review explains how senolytics and senomorphics target senescent cells differently, and why entering trials does not establish patient benefit.
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Evidence date ·How a lymphatic bypass in the neck could affect brain clearance
Review or Meta-AnalysisA 2025 review examines neck lymphatic bypass, early cognitive-score changes, and why fluid pressure and comparison groups matter for Alzheimer’s research.