Research area
Health & Longevity
Human health, disease, treatment and aging. The largest corpus area supports distinct cancer, neurological and therapeutic navigation.
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Evidence date ·When aging changes what stem cells say to surrounding tissue
Review or Meta-AnalysisA 2021 review traces how aging changes mesenchymal stem-cell signals, what small human studies measured, and why vesicle treatments remain experimental.
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Evidence date ·How metabolism shapes cells that stop dividing but remain active
Review or Meta-AnalysisA 2021 review links senescent cells to blood-sugar dysfunction and compares prevention, signal suppression, and removal without proving patient benefit.
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Evidence date ·How diabetes can disrupt heart repair cells before old age
Peer-Reviewed PaperTracked over timeRemoving senescent cells improved growth in cultured human cardiac cells and heart function in diabetic mice. Benefits in patients remain unproven.
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Evidence date ·How ageing immune cells may strain the diabetic heart’s fuel system
Review or Meta-AnalysisTracked over timeA 2021 review links immune-cell ageing, inflammation and altered heart fuel use, while mouse results stop short of showing patient benefit.
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Evidence date ·How engineered immune cells might be designed and delivered for glioblastoma
Review or Meta-AnalysisA 2021 review explains how engineered T and natural killer cells face changing tumour targets, difficult delivery and uncertain durability in glioblastoma.
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Evidence date ·What dasatinib and quercetin changed in the aging mouse intestine
Peer-Reviewed PaperIn a ten-week mouse study, two drugs lowered gut markers of cellular senescence and inflammation. Bacterial changes varied by region; human benefit remains unproven.
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Evidence date ·How cell-to-cell messages could help repair aging tissues
Review or Meta-AnalysisA 2021 review traces how extracellular-vesicle cargo alters recipient cells, what mouse experiments show, and why tissue repair needs human validation.
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Evidence date ·How aging and cancer treatment leave cells that still send signals
Review or Meta-AnalysisCells that stop dividing can still release signals that affect tumors. A 2021 review separates this activity from cancer cells returning to division.
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Evidence date ·New Zealand’s local cancer cell therapy raises bigger care questions
Clinical TrialA 2021 paper describes local manufacturing for ENABLE and asks how delivery, Māori guardianship and equitable access could shape cancer cell therapy.
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Evidence date ·How a porous scaffold could link tumor injury to immune action
Review or Meta-AnalysisTracked over timeA 2026 review explains how porous frameworks alter tumor chemistry, trigger immune signals in mice, and face limits in activation, breakdown, and production.