Editorial team
ioQuanta Research Desk
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Evidence date ·Why does CD30’s location matter across skin tumors?
Review or Meta-AnalysisA 2021 review found CD30 on tumor cells in some solid skin tumors, but frequently on nearby immune cells. The distinction matters for testing targeted treatments.
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Evidence date ·Why two PD-L1 scores tell different stories in gastroesophageal cancer
Review or Meta-AnalysisTracked over timeA review of 17 trials found that tumor-cell PD-L1 scores were more informative in squamous cancer, while combined scores stood out in adenocarcinoma.
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Evidence date ·What tumor genes may add to PD-L1 testing in gastroesophageal cancer
Peer-Reviewed PaperTracked over timeIn gastroesophageal cancer, RAS-MAPK changes were linked to longer survival after immunotherapy; TP53 mutations were linked to shorter survival in one subgroup.
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Evidence date ·Many tumor T cells are bystanders. Turning them into treatment is hard
Review or Meta-AnalysisMany T cells inside tumors are bystanders. A 2021 review explains the hurdles in selecting cancer-reactive cells, keeping them active, and manufacturing treatments.
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Evidence date ·How breast tumors use immune checkpoints—and why researchers are trying to block them
Review or Meta-AnalysisA March 2021 review describes how tumors activate immune-suppressing checkpoints and why breast cancer trials sought greater efficacy with fewer immune-related side effects.
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Evidence date ·Why did engineered immune cells reach ovarian tumors without controlling them?
Review or Meta-AnalysisDNA from engineered cells was found in tumor biopsies during a 15-patient study, yet antitumor activity was minimal. The review examines target choice and persistence.
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Evidence date ·Why can moisture help graphite slide but undermine molybdenum disulfide?
Review or Meta-AnalysisA 2021 review explains why moisture can ease graphite sliding yet raise friction in molybdenum disulfide films, and why low friction alone cannot ensure durability.
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Evidence date ·Why the way carbon nanotubes connect changes what a polymer can do
Review or Meta-AnalysisA 2021 review explains how amino coating helped nanotubes disperse and form conductive paths in epoxy at 0.13% by weight; untreated tubes needed 0.51%.
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Evidence date ·Could a whole tumor vaccine help the immune system recognize more of glioblastoma?
Review or Meta-AnalysisFor glioblastoma, a 2021 review proposes using irradiated tumor cells to help the immune system recognize more targets. The main results came from colon cancer mice.
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Evidence date ·Why ready-made donor cells may not keep blood cancers in check
Review or Meta-AnalysisA 2021 review describes early donor natural killer cell trials and an investigational bank, showing the appeal of faster supply and the challenge of keeping cells active.